An Observed Entanglement of Lagenorhynchus obliquidens in the High Seas Driftnet Area in the North Pacific

In August, 1991, an entanglement event was observed in the High Seas Driftnet area in the North Pacific. This description of an entanglement of Lagenorhynchus obliquidens is the first such documented report of dolphins entangling while bowriding. One of the entangled dolphins was rescued from the driftnet

The Effects of Students’ Middle-School and High-School Experiences on Completion of the Bachelor’s Degree: How Can School Counselors Make a Difference?

Trusty and Hutchinson present a brief overview and analysis of the Research Monograph, Effects of Students’ Middle-School and High-School Experiences on Completion of the Bachelor’s Degree. They offer a discussion of the association between certain middle and high school student variables on the completion or non-completion of the bachelor\u27s degree. In addition, they provide best practices and suggestions for school counselors to apply the findings to their own contexts

Morphine activates neuroinflammation in a manner parallel to endotoxin

Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors. We demonstrate that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation. Small-molecule inhibitors, RNA interference, and genetic knockout validate the TLR4/MD-2 complex as a feasible target for beneficially modifying morphine actions. Disrupting TLR4/MD-2 protein–protein association potentiated morphine analgesia in vivo and abolished morphine-induced proinflammation in vitro, the latter demonstrating that morphine-induced proinflammation only depends on TLR4, despite the presence of opioid receptors. These results provide an exciting, nonconventional avenue to improving the clinical efficacy of opioids.Xiaohui Wang, Lisa C. Loram, Khara Ramos, Armando J. de Jesus, Jacob Thomas, Kui Cheng, Anireddy Reddy, Andrew A. Somogyi, Mark R. Hutchinson, Linda R. Watkins and Hang Yi

The Impact of the Civil War on Capital Intensity and Labor Productivity in Southern Manufacturing

The Civil War resulted in a substantial divergence in the regional structure of factor prices. In particular, wages fell in the South relative to the non-South, but interest rates and other measures of the costs of capital increased. Using archival data for manufacturing establishments, we show that capital-output and capital-labor ratios in southern manufacturing declined relative to non-southern manufacturing after the War, precisely in the direction implied by the regional shifts in factor prices. Labor productivity in Southern manufacturing also declined, but this decline is explained by the reduction in capital intensity.

Enhancing choice? The role of technology in the career support market

This report explores the role that technology has played in the development of the career support market. This market is conceived broadly to include all possible resources that individuals might draw upon to support them in their career development. A key element is the role that is played by public-sector career services and by careers professionals; though these resources are supplemented by services paid for in a wide range of ways and delivered by a range of professionals and non-professionals.UKCE

Careering through the Web: the potential of Web 2.0 and 3.0 technologies for career development and career support services

This paper examines the environment that the web provides for career exploration. Career practitioners have long seen value in engaging in technology and the opportunities offered by the internet, and this interest continues. However, this paper suggests that the online environment for career exploration is far broader than that provided by public-sector careers services. In addition to these services, there is a wide range of other players including private-sector career consultants, employers, recruitment companies and learning providers who are all contributing to a potentially rich career exploration environment.UKCE

Novel Dynamical Resonances in Finite-Temperature Bose-Einstein Condensates

We describe a variety of intriguing mode-coupling effects which can occur in a confined Bose-Einstein condensed system at finite temperature. These arise from strong interactions between a condensate fluctuation and resonances of the thermal cloud yielding strongly non-linear behaviour. We show how these processes can be affected by altering the aspect ratio of the trap, thereby changing the relevant mode-matching conditions. We illustrate how direct driving of the thermal cloud can lead to significant shifts in the excitation spectrum for a number of modes and provide further experimental scenarios in which the dramatic behaviour observed for the $m=0$ mode at JILA (Jin {\it et al.} 1997) can be repeated. Our theoretical description is based on a successful second-order finite-temperature quantum field theory which includes the full coupled dynamics of the condensate and thermal cloud and all relevant finite-size effects